KMID : 0043320170400030318
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Archives of Pharmacal Research 2017 Volume.40 No. 3 p.318 ~ p.327
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Oleanane triterpenoids from Akebiae Caulis exhibit inhibitory effects on A¥â42 induced fibrillogenesis
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Chowdhury Anisuzzaman
Ko Hae-Ju Lee Hwan Haque Aminul Park Il-Seon Lee Dong-Sung Woo Eun-Rhan
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Abstract
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Previous phytochemical investigations of Akebiae Caulis resulted in the isolation of triterpenes, triterpene glycosides, phenylethanoid glycosides and megastigmane glycoside. Amyloid beta (A¥â), the main component of the senile plaques detected in Alzheimer¡¯s disease, induces cell death. However, only a limited number of studies have addressed the biological and pharmacological effects of Akebiae Caulis. In particular, the inhibitory activity of Akebiae Caulis against A¥â42 fibrillogenesis remains unclear. Herein, a new triterpene glycoside, akequintoside F (1), along with nine known compounds pulsatilla saponin A (2), collinsonidin (3), akebonic acid (4), hederagenin (5), 1-(3¡Ç,4¡Ç-dihydroxycinnamoyl) cyclopentane-2,3-diol (6), asperosaponin C (7), leontoside A (8), quinatic acid (9), and quinatoside A (10) were isolated from Akebiae Caulis using repeated column chromatography with silica gel, LiChroprep RP-18, and MCI gel. The chemical structures of compounds 1?10 were illustrated based on 1D and 2D NMR spectroscopy, including 1H-1H COSY, HSQC, HMBC and NOESY spectroscopic analyses. Compound 1 a novel compound and known compounds 6 and 7 were isolated for the first time from this plant. Among these compounds, 1, 3, 4, 5 and 7 displayed significant inhibitory effects on A¥â42 induced fibrillogenesis. We present the first report of new compound 1 and the inhibitory effects of components from Akebiae Caulis on A¥â42 fibrillogenesis.
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KEYWORD
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Akebiae Caulis, Lardizabalaceae, Oleanane triterpenoid, A¥â42, Fibrillogenesis
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